From a pathophysiological perspective, several hypotheses allied to AD have been studied to help understand this multifactorial disorder (amyloid cascade, cholinergic and the vascular hypotheses).11,12 The well documented pathological hallmarks of AD incorporate amyloid-β peptide (Aβ) plaques, tau tangles, neuroinflammation, and subsequent neurodegeneration.10 Aβ can be found both in the brain parenchyma, or in and around blood vessels (cerebral amyloid angiopathy).13 A competing hypothesis (to the amyloid cascade hypothesis) is the vascular hypothesis of AD. This evidence concerns the gene MAPT and Alzheimer disease.