The short‐term and limited residence of NIP at the tumor site may associate with the EPR effect.[28] For the mice injected with DFCR‐MIP, the injected DFCR‐MIP mainly resided at the liver and started to slowly accumulate at the tumor site after 3 days; the resided time at the tumor site was as long as dt‐MIP and SA‐MIP did. The gene discussed is MIP; the disease is neoplasm.