The analysis of biological characteristics and bioinformatics mentioned above strongly suggested that the upregulated ZNF300 induced by cisplatin might be of special importance in the invasion, metastasis and other malignant progression of NSCLC because SCLC, anaplastic oligodendroglioma, glioblastoma, skin basal cell carcinoma, invasive ductal breast carcinoma and invasive lobular breast carcinoma are all highly aggressive and malignant tumours. The gene discussed is ZNF300; the disease is non-small cell lung carcinoma.