The analysis displayed that most of the genes associated with growth, differentiation, MAPK/ERK pathways and cyclin‐dependent kinase inhibitor were downregulated, whereas most of the genes associated with cyclin‐dependent kinase, cell cycle checkpoint, cell division, cell cyclins, G2/M DNA damage checkpoint and cancer stemness were upregulated in A549‐ZNF300 cells compared to A549‐ZNF300‐NC cells. This evidence concerns the gene MAPK1 and cancer.