In the study, we also observed a slow‐cycling phenotype and higher expression of p53 in chemoresistant cells compared to chemosensitive cells, but there was no significant difference of p53 expression between A549‐ZNF300 and A549‐ZNF300‐NC cells, or between A549/DDP‐shZNF300 and A549/DDP‐shZNF300‐NC cells (Figure S5B), demonstrating that p53 might be involved in the chemoresistance and malignant progression of NSCLC though not be regulated by ZNF300. The gene discussed is ZNF300; the disease is non-small cell lung carcinoma.