The apoptosis of A549‐ZNF300 and A549/DDP‐shZNF300‐NC cells induced by cisplatin was significantly lower than that of A549‐ZNF300‐NC and A549/DDP‐shZNF300 cells (Figure 1E), demonstrating that ZNF300 mediated the chemoresistance of NSCLC, which was confirmed in the subcutaneous tumour xenograft model. Here, ZNF300 is linked to neoplasm.