Whether MOG encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease [MOGAD]), a rare autoimmune disease characterized by serum immunoglobulin G antibodies (IgG) against myelin oligodendrocyte glycoprotein (MOG) and overlapping clinical and radiological features with both NMOSD and multiple sclerosis (MS) [4–7, 11], may occur in a paraneoplastic context is less well known. The gene discussed is MOG; the disease is multiple sclerosis.