Differential abundance of alcohol dehydrogenase (ADH) support this hypothesis: in fact ADH, an enzyme involved in carbon/energy metabolism, resulted down-regulated by CiTS-dm exposure respect to control, while no difference was found after BeTS-dm treatment; similar results were already reported for mHtcum, which was effective in lowering both AF and sclerotia biosynthesis28, suggesting for the dimethylated form of CiTS at least one possible target up-stream AF and sclerotia-forming processes. Here, AVP is linked to atrial fibrillation.