CD4 and palmoplantar pustulosis: However, when lymphocyte subpopulations were examined, PPP patients were found to have significantly lower numbers of CD3+ T cells (p = 0.001), CD4+ T cells (p = 0.005), CD8+ T cells (p = 0.003), and B cells (p = 0.005), but higher proportion of NK cells (p = 0.02) than PPN patients (Fig. 1A,B).