To investigate this hypothesis, we selected SNVs located in DHS regions from 20 cancer-types from 2658 tumor samples from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium34 and calculated, for each TF, its Δgainability, Δdisruptability, Δhitability and Δrobustness scores relative to the background reference scores based on a uniform mutational frequency (all possible SNVs) in DHSs. This evidence concerns the gene TF and cancer.