In the present study, we aimed to: (1) establish whether the association of FMRP target genes with schizophrenia correlates with binding confidence; (2) determine whether the FMRP gene set association can be explained by alternative characterisation or functional annotation of genes; and (3) demonstrate the extent to which FMRP targets are associated with risk across a range of psychiatric disorders. This evidence concerns the gene FMR1 and schizophrenia.