FMR1 and major depressive disorder: Beyond background association from brain-expressed genes, FMRP targets from mouse cortex annotated for membership of the 35 overrepresented pathways were strongly associated with bipolar disorder (β = 0.23, corrected P = 1.6 × 10−5) and major depressive disorder (β = 0.21, corrected P = 1.6 × 10−5), whilst genes from the same functional terms not targeted by FMRP harboured no significant association (bipolar disorder: β = 0.037, corrected P = 0.38; major depressive disorder: β = 0.031, corrected P = 0.49) (Table 3).