Put together, when genetic loss of HIF1A occurs without genetic loss of L2HGDH in ccRCC, the survival is significantly greater than when there is simultaneous genetic loss of HIF1A and L2HGDH, which argues against HIF1A being a target of 14q deletion, and against HIF1A being a 14q tumor-suppressor in ccRCC. Here, L2HGDH is linked to nonpapillary renal cell carcinoma.