In ccRCC patients with complete (uncensored) survival data (TCGA), patients with “HIF1A shallow deletion + L2HGDH diploid” (n = 5) had significantly greater mean survival (1670.8 days; 95% CI 1311.1–2030.5, n = 5) compared to patients with “HIF1A shallow deletion + L2HGDH shallow deletion” (885.1 days, 95% CI 798.9–971.3, n = 87) (t-test p value = 0.007) (Fig. 3C). The gene discussed is L2HGDH; the disease is nonpapillary renal cell carcinoma.