HIF1A and nonpapillary renal cell carcinoma: Most importantly, HIF1α data from this large cohort of ccRCC patients (TCGA) at the mRNA (n = 530) and protein (n = 444) levels showed that it has no impact on survival, arguing against the claim that HIF1α functions as a tumor suppressor in the only malignancy in which it has been claimed to have this role.