Furthermore, recently, HIF2α inhibitor-resistant ccRCC patient-derived xenograft tumors were observed to have significantly greater HIF1A mRNA expression than HIF2α inhibitor-sensitive ccRCC tumors, raising the possibility that HIF1α may be particularly oncogenic in ccRCC tumors with no response despite HIF2α inhibition43. The gene discussed is HIF1A; the disease is nonpapillary renal cell carcinoma.