This study also refutes the labeling of HIF1α as a target of 14q deletion in kidney cancer, and the claim that the poor prognosis of 14q-deleted ccRCC patients is due to genetic loss of HIF1A (by revealing a high degree of HIF1A preserved-allele compensation and its relation with recently characterized ccRCC tumor suppressor L2HGDH in 14q deletions). The gene discussed is L2HGDH; the disease is kidney cancer.