Furthermore, this article shows that 14q loss in ccRCC results in much greater reduction in L2HGDH levels than HIF1A levels, indicating much lower preserved-allele compensation of L2HGDH than HIF1A. Lastly, when genetic loss of HIF1A occurs without genetic loss of L2HGDH in ccRCC, the survival is significantly greater than when there is simultaneous genetic loss of HIF1A and L2HGDH. These data, as well as the comparative expression and survival analyses presented in this article (Table 1 and Figs. S1–S3) make L2HGDH a far better candidate for a “target of 14q deletion”. This evidence concerns the gene L2HGDH and nonpapillary renal cell carcinoma.