HIF1A has been termed a ‘target of 14q deletion’ in ccRCC and a kidney cancer suppressor gene, based on these functional proliferation studies in ccRCC cell lines, the adverse prognosis of 14q-deleted ccRCC patients (large 14q deletions are seen in ~ 40% of ccRCC) and loss of function mutations of HIF1A (HIF1A mutation occurs in ~ 1% of ccRCC tumors (TCGA)35. This evidence concerns the gene HIF1A and nonpapillary renal cell carcinoma.