HIF1A and clear cell renal carcinoma: Of all the 28 genes (including HIF1A and LHGDH), L2HGDH had the greatest percentage reduction in expression in clear cell renal cancer compared to normal kidney (40% reduction in log2(TPM + 1)), followed by PELI2 (38%) and CDKL1 (33%) (TCGA, Fig. S2A–C).