Of the 76 total protein-coding genes between L2HGDH at 14q21.3 and HIF1A at 14q23.2 (also deleted in ≥ 95% of 14q deletions in ccRCC involving HIF1A), there were 26 genes whose lower expression was significantly associated with inferior survival (log-rank p < 0.05), and are yet to be functionally characterized in ccRCC. This evidence concerns the gene L2HGDH and nonpapillary renal cell carcinoma.