Lately, adipocytes were mainly considered to be great energy storage and provided high-energy metabolites in the TME.61 For example, CAAs released exogenous FFAs, which were taken up by cancer cells via cell surface CD36.62 Additionally, FFAs could provide sufficient energy for cancer cells through FAO.63 Thus, CAAs can regulate the metabolic reprogramming of cancer cells, which in turn promote cancer progression. This evidence concerns the gene CD36 and cancer.