HIF1A and neoplasm: It could be speculated that exosomal miR-155 was associated with the tumor-promoting process.64 A study from Yogev et al.106 reported that KSHV-infected cells transferred the miRNAs to surrounding cells through secreting exosomes, which resulted in a metabolic reprogramming toward the glycolysis, decreased mitochondrial biogenesis and the stabilization of HIF1α in the non-infected cells.