Some studies have found FAO-related proteins in adipocytes-derived exosomes through proteomics analysis, and these exosomes could induce metabolic reprogramming in melanoma cells for the benefit of FAO.67,68 Another study showed pancreatic cancer (PC) cells-secreted exosomes containing adrenomedullin (AM) interacted with adrenomedullin receptors (ADMRs) in adipocytes, and activated MAPKs p38 and ERK 1/2 signaling pathways and induced lipolysis through HSL phosphorylation.139. Here, ADM is linked to pachyonychia congenita.