Glycolysis is a hallmark of tumor ECs, and the ECs in the tumor vasculature depend more on glycolysis to produce ATP than normal ECs.71 A hyperglycolytic phenotype was confirmed in tumor ECs, which is evidenced by the enhanced expression of the glycolytic key enzyme PFKFB3 and the glucose transporter GLUT1.71 The gene discussed is PFKFB3; the disease is neoplasm.