In addition, HISLA expression level was associated with glycolysis, poor chemotherapy effect, and low survival rate of breast cancer patients, indicating EVs-packed HISLA as an independent prognostic biomarker in breast cancer patients.93 Another study revealed that adrenomedullin (AM) was significantly upregulated in plasma exosomes from patients with pancreatic cancer (PC) compared to non-PC control patients. This evidence concerns the gene HISLA and pachyonychia congenita.