Furthermore, EVs packaged LMP1 markedly increased the important pre-metastatic niche factors (S100A8, VEGFR1 and fibronectin) levels by stimulating CAFs in vivo favored the establishment of pre-metastatic niche in nasopharyngeal carcinoma.54 Primary prostate cancer (PCa) cells transferred exosomes containing PKM2 into bone marrow stromal cell. This evidence concerns the gene PKM and Familial prostate cancer.