TGFB1 and neoplasm: The reprogramming TAMs promoted anti-inflammatory immunosuppression by increasing the expression of TGF-β.86 Similarly, pancreatic cancer cells-derived exosomes induced M2 polarization of macrophages by activating PTEN/PI3Kγ pathway.87 Oppositely, a few studies have also shown that tumor-derived exosomes triggered M1 polarization in macrophages.88,89