Intriguingly, lactates exported from cancer cell upregulated HISLA in TAMs and promotes the feed-loop between TAMs and cancer cells.93 Recently, Wang et al. showed that oxaliplatin-resistant colorectal cancer cells-derived exosomal ciRS-122 was a sponge of miR-122, which enhanced PKM2 protein expression, thus increased the glycolysis and decreased the drug sensitivity in the sensitive cancer cell. Here, PKM is linked to cancer.