PPARG and neoplasm: Meanwhile, inhibition of exosomal miR-122 could rescue glucose metabolism in distant organs, such as lungs and brain, and decreased the incidence of tumor metastasis in vivo, which demonstrated that exosomal miR-122 was able to remodel systemic energy metabolism to promote tumor progression.115 In another study, Wu et al. showed that miR-155 directly targets peroxisome proliferators-activated receptor γ (PPARγ).