The neovascularization supplies nutrient and oxygen to cancer cells, which support tumor progression and provide pathways for tumor metastasis.69 The sustained hypoxia, combined with the secretion of cytokines, such as VEGF, facilitates tumor revascularization by triggering the remodeling of endothelial progenitor cells that are derived from bone marrow toward cancer.70 This evidence concerns the gene VEGFA and neoplasm.