Wu and colleagues found that IRS1 is the direct target of miR-126, and the exosomal miR-126 derived from breast cancer cells induced metabolic reprogramming in adipocytes, including inducing the catabolism after the disruption of IRS/Glut-4 signaling pathways, activating the AMPK/autophagy pathways and stabilizing the expression of HIF1α. Here, HIF1A is linked to breast carcinoma.