Glycolysis is a hallmark of tumor ECs, and the ECs in the tumor vasculature depend more on glycolysis to produce ATP than normal ECs.71 A hyperglycolytic phenotype was confirmed in tumor ECs, which is evidenced by the enhanced expression of the glycolytic key enzyme PFKFB3 and the glucose transporter GLUT1.71 This evidence concerns the gene SLC2A1 and neoplasm.