Recently, Petanidis S et al.122 isolated exosomes from patients with Kras chemoresistant lung cancer patients.122 Exosomes can remodel metabolism in a PKM2-dependent manner to maintain lung cancer cell metabolic chemoresistance.122 Therefore, these data show that exosomes secreted by the cancer cells promote the drug resistance by remodeling the metabolism. This evidence concerns the gene PKM and cancer.