The exosomal lncRNA SNHG3, as a sponge of miR-330-5p, positively regulated the expression of PKM, inhibited the OXPHOS, increased glycolysis, and promoted breast cancer cells proliferation.98 Another study found that miR-105-containing exosomes derived from breast cancer cells could induce metabolic reprogramming in the CAFs. This evidence concerns the gene PKM and breast cancer.