Curcumin extract, when applied both topically and orally, acts as an antiseptic and decreases inflammation by downregulating the levels of inflammatory cytokines such as TNF-α, IFN-γ, IL-2, IL-17A, IL-17F, IL-22 and IL-23, thereby reducing both parakeratosis and hyperkeratosis in the psoriatic lesions11,12. The gene discussed is TNF; the disease is Hyperkeratosis.