Both THC-mediated inhibition of keratinocyte proliferation and cannabinol (CB)-1 activation are believed to be crucial for the treatment of psoriasis via the reduction of inducible factor-1 α (HIF-1 α), vascular endothelial growth factor, basic fibroblast growth factor (bFGF), angiopoietin-2, IL-8, IL-17 and IL-213. The gene discussed is CXCL8; the disease is psoriasis.