Moreover, SLC25A22 has been identified as a synthetic lethal gene in colorectal cancer cells with KRAS mutations.65 The inhibition of PLK1 and RhoA/Rho kinase (ROCK) has a synergistic effect in KRAS-mutant cancers,66 which is a more complex condition of SL in genetics involving these three genes. The gene discussed is PLK1; the disease is cancer.