SMARCA4 and malignant colon neoplasm: It was observed that the proliferation of tumors was inhibited.79 Based on this finding, SL between ARID1A and ARID1B could possibly be expanded and applied to more ARID1-mutant tumor cells such as hepatocellular carcinoma (HCC) and colon cancer.80 The other two subunits SMARCA2 and SMARCA4 that make up the SWI/SNF complex share a similar relationship, as SMARCA2 is essential for the survival of tumor cells that possess function mutations in SMARCA4.81,82