Through RNAi assay, Steckel et al. conducted a series of studies to illuminate the synthetic lethal interactions that DNA replication regulator CDC6 and transcription factor GATA2 have with KRAS.63,64 Downstream regulatory pathways of GATA2 were further studied in NSCLC, which are described in the next section—synthetic lethal pathways. Here, GATA2 is linked to non-small cell lung carcinoma.