IGF1 and cancer: Among the genes with increased 5hmC density in PDAC were those related to pancreas development (GATA429, GATA629, PROX130, ONECUT131, and MEIS232) and/or implicated in cancer (YAP133, TEAD133, PROX134, ONECUT2, ONECUT1, and IGF1) (Fig. 3b).