In this report, we present the utility of our synthetic stress in harmonized data sets; additional efforts to show, including in Black samples, that common variation in EBF1 may contribute to inter-individual differences in human obesity in the presence of stress; a systematic evaluation of sex, race, and age interactions with EBF1 gene-by-stress association to identify the precise risk group; and also the evaluation of its clinical implication, i.e., a path linking EBF1 and stress to obesity to fasting blood glucose to the development type 2 diabetes mellitus in the risk group. Here, EBF1 is linked to type 2 diabetes mellitus.