MAPT and Alzheimer disease: Accumulating evidence suggest that hyperphosphorylated or misfolded conformers of the microtubule associated protein Tau, which accumulates as aggregates in several neurodegenerative diseases including Alzheimer’s disease (AD) and some forms of frontotemporal dementia, have the ability to “spread” through the brain [4, 5, 7, 12, 20, 23].