CAMK2A and Alzheimer disease: In older animals, the expression of CaMKIIα (p = 0.367), SYP (p = 0.126) and RNA Pol II (p = 0.369) was unaltered in AT8 positive neurons compared to AT8 negative tau transgene overexpressing neurons (Fig. 3a, c), again contrasting with expected results from human AD tissues.