FLT3 and acute myeloid leukemia: Venetoclax alone strongly reduced the ability of primary AML cells to form colonies compared to control dimethyl sulfoxide, (DMSO; p < 0.001 for FLT3-ITD and p = 0.006 for FLT3-WT) (Fig. 2c, d), and we did not find a statistically significant difference between treatment with venetoclax and treatment with venetoclax plus midostaurin on the aggregate data.