ATG5 and mantle cell lymphoma: In contrast, in SP53 and JEKO-1 MCL cells, repression of autophagy by knockout of ATG5, a component of the phagophore elongation complex in autophagy, by lentivirus-mediated CRISPR-Cas9, resulted in inhibition of cellular proliferation and increase of apoptosis [44], suggested the oncogenic role of autophagy for lymphoma.