Since miR-342-3p has been shown to target DNMT1 by luciferase reporter assay, and overexpression of miR-342-3p could result in promoter DNA hypomethylation and hence re-expression of hypermethylated tumor suppressor genes in colorectal cancer cells [25], we hypothesized that overexpression of miR-342-3p in completely methylated lymphoma cells would result in downregulation of DNMT1 and hence hypomethylation and re-expression of tumor suppressor genes. The gene discussed is DNMT1; the disease is colorectal cancer.