This suggests that EOfAD-like mutations in sorl1 are not as disruptive to cell function as EOfAD-like mutations in psen1. Campion and colleagues [23], noted that carriers of the C1478* mutation generally had an age of onset closer to the established LOAD threshold of 65 years, which arbitrarily defines the difference between early and late onset AD, and that unaffected, aged (≥ 66 years of age), carriers of this mutation exist. The gene discussed is PSEN1; the disease is Alzheimer disease.