The only eligible African study showed that the TP53 p.Arg72Pro polymorphism is highly associated with the risk of breast cancer as well in the recessive model (OR = 2.14, 95% CI = 1.08–4.23, P = 0.03) than in the additive model (OR = 1.49, 95% CI = 1.03–2.16, P = 0.03). Here, TP53 is linked to breast cancer.