TRIM28 and cutaneous melanoma: Firstly, using RNA Seq V2 RSEM data from the cBioportal database [21,22] for the skin cutaneous melanoma (SKCM) patients (n = 469), we analyzed the distribution of TRIM28 expression in tumor samples resulting in discrimination of 117 samples (25%) with robustly elevated TRIM28 denoted as TRIM28HIGH (Figure 1A).