Through microarray analysis and subsequent validation in real-time PCR, we identified six transcripts showing differential expression; in particular, GS1-304P7.3 was upregulated in the AD group compared to the CTRL group, while NONHSAT090268, TC0100011037, TC0400008478, TC1400008125, and UBE2V1 showed reduced expression in AD plasma samples compared to the CTRL group. This evidence concerns the gene UBE2V1 and Alzheimer disease.