GPC3 and hepatocellular carcinoma: Similarly, the results of this study revealed that chrysin alone and its combination with cisplatin markedly reduced cellular GPC3 protein, immunostaining, as well as mRNA expressions in HepG2 cells, compared to untreated HepG2 cells in a dose- and time-dependent manner, confirming the involvement of GPC3 suppression as a novel antiproliferative mechanism for chrysin against HCC.