On the other hand, it has been found that the family of heparin-degrading endosulfatases involving SULF1 and SULF2 were implicated in the pathophysiology of numerous cancers, including HCC with an opposing action either as a tumor suppressor action with SULF1 or as an oncogenic action with SULF2. The gene discussed is SULF1; the disease is hepatocellular carcinoma.