In the breast cancer cell line MCF7, P4 elicits changes in the expression of S100A11, S100A10, calreticulin, VDAC1, SERCA3, and SERCA1, resulting in a barely Ca2+ efflux from the endoplasmic reticulum as well as impaired membrane potential in the mitochondria [64]. The gene discussed is CALR; the disease is breast cancer.