PGRMC1 and cancer: So, during cancer onset, PGRMC1 might be temporally downregulated, and thus, cancer cells might avoid the negative effect of P4 in proliferation (shown in Figure 7 and Figure 8), and in parallel, these cells might get the benefit of the activation of NFAT1 that would allow the MDA-MB-231 cells to migrate and initiate other cancer sprouts (shown in Figure 9).