The involvement of human papillomavirus (HPV), as well as p53 and p16 biomarkers, have been shown to be involved in the genesis of cancers located in the oropharynx, as well as the junction of the retromolar trigone with the oropharynx, a particular area due to the fact that it is at the border of two territories, namely, ENT and OMF surgery. Here, CDKN2A is linked to cancer.