However, the decreased levels of NANOG and SOX2 observed upon HMGB1 or HMGB1/2 double KD (Figure 1E,F) had no impact on the pluripotency of hESCs, as revealed using a teratoma formation assay, in which no tangible deviation from the normally differentiated teratoma morphology was demonstrated [10]. Here, SOX2 is linked to teratoma.