BTRC and Miyoshi myopathy: Specifically, authors have demonstrated the presence of DNA methylated peaks within intragenic and intronic regions, in MM; and found hypermethylation-mediated inhibition of tumor suppressor-miRNA-10b-5p, and -miRNA-152, thus leading to overexpression of their target genes (oncogenes DNMT1, BTRC, MYCBP, and E2F3) in CD138+ bone marrow derived MM cells [29].