LACC1 and colitis: As shown in this study, LACC1 knockout mice showed worse disease in the Citrobacter rodentium model of colitis, and the collagen-induced arthritis models, compared to wild type (WT) mice, while there were no differences identified between LACC1 KO and WT in the dextran sulfate sodium (DSS) model of colitis and the K/BxN model of arthritis [18].