In addition to PAH, NOX1 has also been shown to participate in PH elicited by CH as evidence by effects of genetic global deletion of NOX1 to abolish the CH-induced elevation in right ventricular systolic pressure (RVSP), right ventricle (RV) hypertrophy and PA remodeling in mice [98]. The gene discussed is NOX1; the disease is pulmonary arterial hypertension.