TRPV4 and cyclic hematopoiesis: Whereas TRPV4 expression in adventitial fibroblasts is upregulated by CH and contributes to excessive adventitial remodeling during the pathogenesis of PH [228], PASMC TRPV4 channels contribute to enhanced pulmonary vasoconstrictor reactivity following CH [204,205,206] (Table 2 for details).