al. found trichotomised GSTP1 methylation to be an independent prognostic predictor (when adjusted for GS, pathological T-stage and pre-op PSA levels) of clinical failure (see Table 1 for definition) in two cohorts (Training: n = 147, Validation: n = 71) of high-risk PCa patients [94]. This evidence concerns the gene GSTP1 and posterior cortical atrophy.