CCND2 and posterior cortical atrophy: In the study by Henrique et al., methylation levels of 5 genes (APC, CCND2, GSTP1, RARB, RASSF1) were quantified by qMSP of DNA extracted from sextant biopsies (n = 83), of which APC was the only gene significantly associated with both BCR and PCa death in univariate and multivariate analyses with other clinicopathological factors.