The earliest of these studies assessed GSTP1 methylation using qMSP in a cohort of GS 7 (3 + 4) patients (n = 74), and reported that GSTP1 hypermethylation was significantly associated with time to progression (any of BCR, metastatic relapse and/or PCa death) in univariate analysis, and as an independent predictor in multivariate analysis with other candidate genes [75]. The gene discussed is BCR; the disease is posterior cortical atrophy.