In the study by Henrique et al., methylation levels of 5 genes (APC, CCND2, GSTP1, RARB, RASSF1) were quantified by qMSP of DNA extracted from sextant biopsies (n = 83), of which APC was the only gene significantly associated with both BCR and PCa death in univariate and multivariate analyses with other clinicopathological factors. Here, APC is linked to posterior cortical atrophy.