In a study of non-neoplastic tissue adjacent to the prostate tumour from PCa patients with follow-up up to 24 years (n = 157), the presence of GSTP1 methylation increased risk of PCa death by almost 3-fold, and remained an independent prognostic factor in multivariate models in combination with APC methylation, GS, age at diagnosis, year of diagnosis, source of tumour tissue and methylation in matched tumour tissue [88]. This evidence concerns the gene APC and posterior cortical atrophy.