In KIR2DL2/L3/S2+ CD8+ T cells cluster analysis of the PPI network identified different modules with up-regulatedgenes that were involved in: (1) signaling pathways of chemokine and cytokine receptors, promoting the release of effector proteins for tumor immune response, such as INFγ or perforin (GO:0019221 cytokine-mediated signaling pathway); and (2) signaling pathways constitutively activated in cancer (HSA-2219528 PI3K/AKT Signaling in Cancer). Here, PRF1 is linked to cancer.