The five most significant terms in KIR2DL1/S1+ CD8+ T cells were GO:0034655 Nucleobase-containing compound catabolic process, R-HSA-1280218 Adaptive immune system, R-HSA-69278 Cell cycle, mitotic, GO:0002366 Leukocyte activation involved in immune system, and GO:0051169 Nuclear transport; whereas for KIR2DL2/L3/S2+ CD8+ T cells the five most significant terms were hsa05330 Allograft rejection, hsa05322 Systemic lupus erythematosus, GO:0019083 Viral transcription, GO:0019221 Cytokine-mediated signaling pathway, and GO:0072657 Protein localization to membrane. The gene discussed is CD8A; the disease is systemic lupus erythematosus.