Both univariate and multivariate analysis indicate the Hb (univariate: OR (95% CI) = 2.29 (1.13–4.64), p = 0.022; multivariate: OR (95% CI) = 2.74 (1.13–6.67), p = 0.026) and miR-486 (univariate: 4.24 (1.14–15.79), p = 0.031; multivariate: OR (95% CI) = 7.54 (1.47–38.6), p = 0.015) were significantly associated with mild cognitive impairment. This evidence concerns the gene GSTM1 and Cognitive impairment.