Recently, new biomarkers such as prostate cancer antigen 3 (PCA3) or marker combinations such as the prostate health index (PHI) or the analysis of four kallikreins (4K) (intact PSA, human kallikrein 2, tPSA and fPSA) score, as well as multiparametric magnetic resonance imaging (mpMRI), have been introduced to improve the accuracy of detecting clinically significant PCa and to help in deciding whether a biopsy is needed [6,7,8]. This evidence concerns the gene PCA3 and posterior cortical atrophy.