IRF1 and osteosarcoma: In particular, miR-663a and ZBTB7A were found to protect osteosarcoma from endoplasmic reticulum stress-induced apoptosis, through the down-regulation of GAS5 [78], while in a similar study the CtBP1-HDAC1/2-IRF1 transcriptional complex was also found to be down-regulated in osteosarcoma cells [79].