Of particular interest is the observation that neuroblastoma-derived EVs are incorporated by mesenchymal stromal cells (MSC)s, where they induce, in a LGALS3BP-dependent manner, the secretion of pro-tumorigenic cytokines and chemokines, including IL-6 and IL-8/CXCL8 [23], providing an opportunity for immune targeting strategies. This evidence concerns the gene CXCL8 and neuroblastoma.