The median of serum galectin-3 concentration was significantly elevated in RA (18.75 ng/mL), SSc (19.4 ng/mL), and SLE (19.2 ng/mL) in comparison to the healthy subjects (9.45 ng/mL) (Z = 5.710, p = 0.000; Z = 5.323, p = 0.000; Z = 3.596, p < 0.001; respectively). The gene discussed is LGALS3; the disease is systemic lupus erythematosus.