Inflammatory signals, such as TNF-α and TGF-β produced by immune cells in the tumor microenvironment, can induce the process of EMT in cancer cells by stimulating expression of proteins associated with EMT, including Snail, Zeb1, and Twist, leading to the degradation of adhesion molecules such as E-cadherin [97,98]. This evidence concerns the gene TGFB1 and neoplasm.