TNF and stroke disorder: In experimental stroke, the systemic inflammatory response signal is characterised by an increased level of cytokines in the serum (interleukin-6, interferon-γ, CXC-chemokine ligand) and the increased production of inflammatory mediators in immune cells (TNF, IL-6, IL-2, CXC-chemokine ligand 12) within a few hours of ischemia [22,23,24].