Together with data reported by Almomani and co-authors on early episodes of ventricular fibrillation in a homozygote carrier of ALPK3, our data stressed the importance of searching for informative ICD implantation criteria in pediatric patients with atypical forms of HCM, including ALPK3-associated cardiomyopathies [4]. This evidence concerns the gene ALPK3 and ventricular fibrillation.