CDH1 and metastatic malignant neoplasm in the lymph nodes: Regarding the prognostic value of E-cadherin in different types of cancer, in a large series of RCC with tumor thrombus (TT) of vena cava (VC), increased expression of E-cadherin was connected with initial lymph node metastasis and with both worse OS (overall survival) and worse CSS (cause-specific survival).