CDH3 and pancreatic ductal adenocarcinoma: On the other hand, in vitro experiments on a pancreatic ductal adenocarcinoma (PDAC) cell line that does not express P-cadherin showed that ectopic expression of P-cadherin (Panc1-CDH3) allowed the PDAC cells to acquire increased motility, which, however, could be blocked by an antibody against P-cadherin.