For instance, a physiological pattern of N-cadherin expression was observed in renal cell carcinoma (RCC) specimens from patients undergoing surgery, despite a high tumor grade, and patients with RCC and normal N-cadherin-expression had a poorer prognosis than those with N-cadherin-abnormal RCC [99]. The gene discussed is CDH2; the disease is hereditary clear cell renal cell carcinoma.