Based on the direct interaction between HPV16 E6 and IRF-1, our results establish that HPV16 E6 regulates the levels of apoptosis mediator protein via attenuation of p53 and acceleration of NF-B activity during IRF-1-induced apoptotic cell death in cervical tumour cells (Figure 4 and Figure 5). This evidence concerns the gene PROS1 and uterine cervix neoplasm.