IL12RB2 and breast carcinoma: Bioinformatic analysis in breast cancer has shown that high expression of IL-12/STAT4 axis molecules, such as the IL-12 receptor genes (IL-12RB1 and IL-12RB2), STAT4, IFNγ, and TBX21, significantly increases the survival rates of patients with breast cancer, especially the more aggressive subtypes [111].