STAT1 and cancer: However, recently, STAT1 has been shown to be associated with poor survival in some cancers [73,74] and has been reported to be responsible for the immunosuppressive tumor microenvironment [75], resistance to therapy, and the potential for metastasis [76,77], and the non-phosphorylated form STAT1 promotes apoptotic resistance by repressing the expression of FAS and BAD genes [78].