AKT1 and cervical carcinoma: More than 90% of cervical cancer samples contain high-risk HPV DNA, and reports exist that the E5, E6, and E7 oncoproteins can alter multiple signaling pathways, such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), Wnt, and Notch, essential pathways in the initiation and maintenance of HPV-associated cancers.