STAT1 and colorectal carcinoma: For example, in colorectal carcinoma and squamous cell carcinoma of the esophagus, STAT1 is associated with a good prognosis, which is not the case for STAT2 [64,65], probably because STAT1 has multiple effects on cell cycle inhibition by the regulation of p21, p27, and the cyclin D1/Cdk4 complex [66].