Our previous work showed that trastuzumab-based liposomes deliver dyes into the nuclei of target tumor cells more efficiently in the in vivo situation, and to a lesser degree in vitro, whereas HER2-scFv based liposomes did not internalize cargos into the nuclei in cultured cells [22] and hence were excluded from in vivo studies then. Here, ERBB2 is linked to neoplasm.