PXR’s implication for playing a role in human cancer metastasis may also stem from it being shown to regulate morphology and cell motility via the signaling axes of PXR GADD45β-p38MAPK and PXR-HNF4ɑ-insulin-like growth factor-binding protein 1 (IGFBP1) [53,54]. The gene discussed is IGFBP1; the disease is cancer.