However, an increase of 120% and 170% in the autophagosome-associated LC3-II/LC3-I ratio and increased sequestosome-1 (SQST1M) and especially autophagy cargo receptor (NBR1) levels (which is involved in the recognition of ubiquitin-modified unknown peroxisomal membrane proteins) in the HF- and HFHS-diet-fed mice indicate the possible blockade of autophagosomal clearance (Figure 8D,E). Here, NBR1 is linked to hydrops fetalis.