FOXO3 and obesity due to melanocortin 4 receptor deficiency: After one week of dexamethasone treatment, we observed induction of Foxo3 and the atrogenes, Trim63 (Atrogin-1) and Fbxo32 (MuRF1), to be greater in obese mice compared to their lean counterparts, though the interaction between obesity status and dexamethasone treatment did not reach statistical significance for these transcripts (Figure 3).