Furthermore, the malignant B cells in Hodgkin’s lymphoma frequently coexpress RANK and RANKL, which are thought to mediate autocrine or paracrine survival signaling, and chronic lymphocytic leukemia (CLL) B cells have been reported to express RANK at increased levels compared with normal B cells (Schmiedel et al., 2013; Secchiero et al., 2006; Wierda et al., 2003). This evidence concerns the gene TNFRSF11A and B-cell chronic lymphocytic leukemia.