BCL2 and B-cell chronic lymphocytic leukemia: This specific clonal CLL phenotype of our model exhibits self-renewal capacity, which is presumably facilitated by an initial RANKK240E-driven expression of survival and proliferation genes such as Bcl-2 or Cyclin-D1 and an expansion of tolerized B1 cells that represent the CLL progenitor population (Hayakawa et al., 2016).