Interestingly, we found that distinct lncRNAs and mRNAs were associated with BE responses in our male and female patient cohorts, with TEK, ERG, NONHSAT095695.2, LDB2, ENST00000552253.1, ENST00000588495.5, CDH5 and MEF2C being tightly linked to BE responses in females, and ENST00000460756.5, G6PC3, ATF6, BMP2, SIX1, RAB7A, ENST00000575695.5, and SOX2 being associated with these responses in males. The gene discussed is G6PC3; the disease is Barrett esophagus.