CD8A and infection: These results were independently confirmed by showing thatpolyclonal CD8 T cells from Erdman-infected mice recognizeΔesxH- andesxHWT-complementedΔesxH-infected macrophages similarly (S8 Fig).Surprisingly, Erd.EsxHWT-elicited CD8 T cells failed to recognizeErd.EsxHA10T-infected macrophages as well asErd.EsxHA10T-elicited CD8 T cells (Fig 5H), despite the ability ofantigen-specific CD8 T cells from both Erd.EsxHWT andErd.EsxHA10Tin vivo infections to activate and recognize their cognateepitopes (Fig 5I).