CD8A and infection: Again,the bacterial loads of in vitro Erd.EsxHWT andErd.EsxHA10T infections were not significantly different (S7B Fig).Thus, natural EsxHA10T polymorphism induce distinct T cell responsesthat affect the ability of elicited T cells to recognize infected macrophages.We next sought to understand mechanistically why the EsxHA10Tpolymorphism abrogated the CD8 T cell response to the TB10.44−11epitope.