IDH2 and acute myeloid leukemia: The recurrent alterations in AML include genes involved in epigenetics (TET2, IDH1/IDH2, DNMT3A, ASXL1, KMT2A, and EZH2), tumor suppressor genes (TP53, WT1, and NPM1), oncogenes (FLT3, KRAS, NRAS, and KIT), and genes coding for transcription-differentiation (CEBPA, RUNX1) [18–20].