Table 3 shows the AUC values for discriminating benign tumors from cancer for the individual proteins. 34 proteins had AUC > 0.7. HE4 (WFDC2) ranked highest with AUC 0.830 (95% CI 0.739–0.921). ROC curves for the six proteins with the highest AUC values are depicted in Fig 1. Table 4 shows the AUC values, sensitivities (95% specificity) and specificities (95% sensitivity) for the reference model with HE4, CA125 and age (AUC 0.838 (0.752–0.924) and for the reference model with the addition of each one of the remaining 32 proteins with AUC > 0.7. This evidence concerns the gene MUC16 and benign neoplasm.