MUC16 and cancer: A six-biomarker model (HE4, CA125, CXCL1, ITGAV, CEACAM1, IL-10RB and age) was the best model for discrimination between benign tumors and borderline tumors + cancer, with AUC 0.868 and sensitivity 0.86 / specificity 0.82 at best point cut-off (p = 0.016) (Table 9 and Fig 4).