Enroth et al. in their recent large-scale study analyzing 593 plasma proteins with PEA, were able to identify a biomarker signature of 11 proteins (CA125, SPINT1, TACSTD2, CLEC6A, ICOSLG, MSMB, PROK1, CDH3, HE4, KRT19, and FR-alpha) plus age to discriminate ovarian cancer (all stages and histologies) from benign disease with a sensitivity of 0.85 at a specificity of 0.93 (AUC = 0.94, PPV = 0.92) [50]. Here, ICOSLG is linked to ovarian cancer.