A six-biomarker model including HE4, CA125, CEACAM1, CTSV, CXCL6, S100A4 and age was found to be the best model for discriminating between benign tumors and EOC with AUC 0.921 (0.863–0.979), sensitivity 0.897 / specificity 0.889 at best point cut-off (p = 0.025) (Table 5 and Fig 2). Here, CTSV is linked to benign neoplasm.