MUC16 and cancer: Table 7 shows the AUC values for discriminating benign tumors from borderline tumors + cancer for the individual proteins. Fifteen proteins had AUC > 0.7. HE4 (WFDC2) ranked highest with AUC 0.767 (0.672–0.861). ROC curves for the six proteins with the highest AUC values are depicted in Fig 3. Table 8 shows the AUC values, sensitivities and specificities for the reference model with HE4, CA125 and age (AUC 0.770 (0.674–0.865)) and for the reference model with the addition of each one of the remaining 13 proteins with AUC > 0.7.